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'Real-life' experience in asthmatic children treated with omalizumab up to six-years follow-up

M M Folqué1, J Lozano1, C Riggioni1

  • 1Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain.

Allergologia Et Immunopathologia
|December 5, 2018
PubMed

Insights

Long-term use of omalizumab in children with allergic asthma significantly reduced exacerbations and hospitalizations. This real-world study found improved lung function and decreased maintenance therapy, with no reported side effects up to six years.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Pharmacology

Background:

  • International guidelines recommend omalizumab for severe asthma.
  • Limited long-term data exist for omalizumab's effects in pediatric populations.
  • Allergic asthma in children poses significant management challenges.

Purpose of the Study:

  • To evaluate the long-term, real-life effectiveness and safety of omalizumab in children with allergic asthma.
  • To assess changes in lung function, medication use, and exacerbation rates.
  • To provide data on omalizumab's impact in a pediatric cohort over an extended period.

Main Methods:

  • An observational, single-center, real-life study design.
  • Data collection included treatment details, lung function (FEV1, FEF25-75%), side effects, exacerbations, and hospitalizations.
  • Patients were monitored at six-month intervals and annually for up to six years.

Main Results:

  • Forty-eight pediatric patients with allergic asthma were enrolled.
  • Significant reductions in fluticasone maintenance dose and cessation of oral corticosteroids were observed.
  • Hospital admissions and emergency department visits for asthma exacerbations decreased significantly.
  • Lung function (FEV1, FEF25-75%) showed statistically significant improvement and remained above normal throughout treatment.
  • No adverse side effects were reported during the six-year follow-up.

Conclusions:

  • Real-life omalizumab treatment in children with allergic asthma is effective in reducing exacerbations and hospitalizations.
  • Omalizumab improves lung function and allows for decreased maintenance therapy in pediatric patients.
  • The treatment demonstrates a favorable safety profile for up to six years in children.
Abstract

Keywords:
OmalizumabPediatric asthma‘Real-life’

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