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Asthma control in preschool children with small airway function as measured by IOS and fractional exhaled nitric

Jing Zeng1, Zhiqiang Chen1, Ying Hu1

  • 1Department of Pediatrics, First Affiliated Hospital to Army Medical University, NO.30, Gao Tanyan Street, Shapingba District, Chongqing, China.

Respiratory Medicine
|December 5, 2018
PubMed

Insights

Impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) effectively assess asthma control in young children. Combining FeNO with the small airway function parameter X5 offers accurate insights into pediatric asthma management.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Allergy and Immunology

Background:

  • Asthma control assessment in preschool children presents unique challenges.
  • Impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) are emerging tools for evaluating pediatric respiratory health.

Purpose of the Study:

  • To investigate the accuracy of combining IOS and FeNO in assessing asthma control among preschool children.
  • To compare the diagnostic performance of individual and combined IOS and FeNO measurements.

Main Methods:

  • Enrolled 79 preschool children with asthma and 25 healthy controls.
  • Utilized IOS to measure respiratory system resistance (R5, R20) and reactance (X5), and FeNO.
  • Classified asthma patients into controlled (n=27) and uncontrolled (n=52) groups based on GINA criteria.

Main Results:

  • Significant differences in small airway parameters (AX, R5-20, R5, X5) and FeNO were observed between controlled and uncontrolled asthma groups (P <0.05).
  • Receiver operating characteristic (ROC) analysis demonstrated superior accuracy for the combined FeNO and X5 measurement (AUC=0.866) compared to individual measures (FeNO AUC=0.786, X5 AUC=0.751).

Conclusions:

  • Fractional exhaled nitric oxide (FeNO) combined with the small airway function parameter X5 accurately assesses asthma control in preschool children.
  • This combined approach offers a promising non-invasive method for monitoring pediatric asthma control.
Abstract

Keywords:
AsthmaAsthma controlChildrenExhaled nitric oxideSmall airway function

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