Related Experiment Video
Updated: Feb 1, 2026
09:03
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
9.9K
Evolution of aneuploidy: overcoming the original CIN
1Department of Molecular Genetics, University of Kaiserslautern, Kaiserslautern 67663, Germany.
Genes & Development
|December 5, 2018
Summary
High chromosomal instability (CIN) can be lethal, but this study in yeast reveals how cells adapt to extreme CIN. These findings illuminate how aneuploid genomes evolve and may impact cancer cell karyotypic evolution.
Area of Science:
- * Cellular biology
- * Genetics
- * Cancer research
Background:
- * Chromosomal instability (CIN) leads to aneuploidy, which can impair cell proliferation due to cellular stress.
- * However, aneuploid genomes might offer survival advantages under adverse conditions.
- * The fate of cells with extremely high CIN remains unclear.
Purpose of the Study:
- * To investigate cellular adaptations to extremely high chromosomal instability (CIN).
- * To elucidate the forces shaping aneuploid genomes in eukaryotic cells.
- * To understand the potential influence of CIN on karyotypic evolution in cancer.
Main Methods:
- * Utilized budding yeast as a model organism.
- * Studied cellular responses and adaptations to mutations causing extreme CIN.
Main Results:
- * Demonstrated that cells can adapt to and survive extremely high levels of CIN.
- * Identified key factors and mechanisms driving the evolution of aneuploid genomes.
- * Provided insights into how cells manage genetic instability.
Conclusions:
- * Cellular adaptations can enable survival despite severe chromosomal instability.
- * The study sheds light on the evolutionary dynamics of aneuploid genomes.
- * Findings may have implications for understanding cancer genome evolution.
Related Concept Videos
02:55The Evidence for Evolution
48.1K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.1K
01:54Convergent Evolution
32.9K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
32.9K
01:24Eukaryotic Evolution
41.4K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
41.4K
02:31Synteny and Evolution
3.8K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.8K
03:21Genome Size and the Evolution of New Genes
9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K
01:22Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
212
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
212