Related Experiment Video
Updated: Feb 1, 2026
07:54
Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy
Published on: December 15, 2011
13.5K
Hepatitis elimination by 2030: Progress and challenges.
Yasir Waheed1, Masood Siddiq2, Zubia Jamil3
1Multidisciplinary Laboratory, Foundation University Medical College, Foundation University Islamabad, Islamabad 44000, Pakistan. yasir.waheed@fui.edu.pk.
World Journal of Gastroenterology
|December 5, 2018
Summary
Global viral hepatitis elimination efforts face significant challenges. Despite progress in hepatitis B vaccination, low diagnosis rates and funding gaps hinder the 2030 targets for hepatitis B and C.
Area of Science:
- Public Health
- Infectious Diseases
- Global Health Policy
Background:
- Viral hepatitis affects over 300 million globally, causing 1.3 million deaths annually.
- The 2016 Global Health Sector Strategy aims to eliminate viral hepatitis by 2030, with only 12 countries currently on track.
- Progress includes high hepatitis B virus (HBV) vaccination rates (87% for 3 doses), but birth dose coverage is only 46%.
Discussion:
- Significant improvements in blood and injection safety are crucial.
- Hepatitis B and C diagnosis rates remain critically low, with only 11% of cases identified, highlighting the need to find 'missing millions'.
- While hepatitis C drug pricing has decreased, only 3 million cases were treated by 2016.
Key Insights:
- Low diagnosis rates and insufficient treatment coverage are major barriers to hepatitis elimination.
- Lack of dedicated funding from global donors and financial constraints in low- and middle-income countries impede hepatitis control programs.
- Achieving hepatitis elimination requires substantial financial investment and political will.
Outlook:
- Hepatitis elimination by 2030 is achievable but necessitates increased global financial commitment and political support.
- Collaboration with civil societies, pharmaceutical companies, and medical industries is essential for successful hepatitis control.
- Sustained efforts in vaccination, diagnosis, treatment, and prevention are vital for future progress.
Related Concept Videos
01:05Elimination Kinetics: First-Order and Zero-Order
2.8K
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
2.8K
02:25Elimination Reactions
17.0K
A nucleophile can react with an alkyl halide to give the substitution product by displacing the halogen. Or it can function as a base to give the elimination product by deprotonation of the neighboring carbon to form an alkene. In an elimination reaction, the substrate loses two groups from adjacent carbons forming at least one π bond. The carbon attached to the halogen is called the α carbon, while the adjacent carbon is called the β carbon; hence, these reactions are called...
17.0K
02:07Tumor Progression
7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
00:51Radical Formation: Elimination
2.4K
Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions with respect...
2.4K
01:30Gaussian Elimination: Problem Solving
192
Systems of linear equations in several variables are pivotal in modeling complex scenarios involving multiple unknowns and constraints. Such systems are widely used in various fields to represent relationships where several conditions must be simultaneously satisfied. Each variable in the system corresponds to an unknown quantity, while each equation imposes a linear constraint, leading to a structured approach for analyzing and solving real-world problems.A system of three equations with three...
192
01:17Kinetics of Drug Elimination
4.2K
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is the half-life of a drug, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is the half-life of a drug, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
4.2K