Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Correlations between validation and definitive study results for genotoxic compounds.

D J Schaeffer1

  • 1Department of Veterinary Biosciences, University of Illinois, Urbana 61801.

Regulatory Toxicology and Pharmacology : RTP
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.

bioRxiv : the preprint server for biology·2025
Same author

Reference intervals and echocardiographic findings in Leonberger dogs.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2020
Same author

Quantitative assessment of two- and three-dimensional transthoracic and two-dimensional transesophageal echocardiography, computed tomography, and magnetic resonance imaging in normal canine hearts.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2019
Same author

Development of a perceived exertion scale for dogs using selected physiologic parameters.

The Journal of small animal practice·2019
Same author

Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats.

Journal of veterinary pharmacology and therapeutics·2017
Same author

Physiological and biochemical variables in captive tigers (Panthera tigris) immobilised with dexmedetomidine and ketamine or dexmedetomidine, midazolam and ketamine.

The Veterinary record·2015
Same journal

Acute Oral Toxicity and Systemic Pathological Effects of Methiopropamine in Female ICR Mice.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Applying the Omics Data Analysis Framework for Regulatory Application (R-ODAF) filtering criteria: A Case Study with 3-Methylcholanthrene.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Cardiovascular toxicity as a globally harmonized system hazard trait: The evidence and the path forward.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

The NTP chronic inhalation study does not support an inherent lung cancer hazard of talc: Implications of lung particle overload and maximum tolerated dose.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Consideration of carcinogenicity and mode of action information by an independent expert panel to support derivation of no-significant-risk-level values for vinyl acetate monomer.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Which carcinogenicity study should I use? Automated identification of reliable studies.

Regulatory toxicology and pharmacology : RTP·2026
See all related articles

Predictive tests require careful validation. A test

Area of Science:

  • Biostatistics
  • Toxicology
  • Assay Development

Background:

  • Predictive assays can reduce costs associated with definitive testing.
  • Validation studies are crucial for evaluating predictive assay performance.

Purpose of the Study:

  • To formally derive statistical definitions for prevalence, sensitivity, and specificity.
  • To establish correlations between predictive and definitive testing tiers.

Main Methods:

  • Derivation of statistical definitions from multinomial distributions.
  • Analysis of correlations under validation and screening study designs.

Main Results:

  • Predictive assay performance can differ between validation and screening phases.

Related Experiment Videos

  • Assays failing validation may still be useful in screening.
  • Well-performing validation assays may show poor correlation in screening.

    • Conclusions:

    • The statistical framework clarifies predictive assay utility.
    • Careful consideration of validation and screening contexts is essential for assay selection.