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A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
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Practical and Scalable Organic Reactions with Flow Microwave Apparatus
Hiromichi Egami1, Yoshitaka Hamashima1
1School of Pharmaceutical Sciences, University of Shizuoka 52-1 Yada, Suruga-ku, Shizuoka, Japan.
Chemical Record (New York, N.Y.)
|December 5, 2018
Summary
This study demonstrates scalable microwave-assisted continuous synthesis using a novel flow microwave system. This approach overcomes scale-up challenges in microwave chemistry for organic reactions.
Area of Science:
- Organic Chemistry
- Chemical Engineering
- Process Chemistry
Background:
- Microwave irradiation accelerates organic reactions in laboratory synthesis.
- Scaling up microwave chemistry is challenging due to limited microwave penetration depth.
- Combining microwave and flow chemistry offers a solution for scaling up microwave-assisted organic reactions.
Purpose of the Study:
- To demonstrate the scale-up of fundamental organic reactions using a novel flow microwave system.
- To summarize progress in scalable microwave-assisted continuous synthesis.
- To highlight the capabilities of the SAIDA flow microwave apparatus.
Main Methods:
- Development of a novel flow microwave system through an academic-industrial alliance.
- Application of the system to fundamental organic reactions.
- Continuous synthesis utilizing microwave irradiation in a flow regime.
Main Results:
- Successful scale-up of organic reactions using the developed flow microwave system.
- Demonstration of efficient and scalable microwave-assisted continuous synthesis.
- Validation of the SAIDA flow microwave apparatus for industrial applications.
Conclusions:
- The novel flow microwave system effectively addresses scale-up challenges in microwave chemistry.
- Scalable microwave-assisted continuous synthesis is achievable with the SAIDA apparatus.
- This technology holds promise for industrial organic synthesis.
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