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Amination of Phosphorodiamidate-Substituted Pyridines and Related N-Heterocycles with Magnesium Amides

Moritz Balkenhohl1, Benjamin Heinz1, Thomas Abegg1

  • 1Department of Chemistry , Ludwig-Maximilians-Universität München , Butenandtstr. 5-13, Haus F , 81377 Munich , Germany.

Organic Letters
|December 5, 2018
PubMed

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Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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