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Platelet TLR4 at the crossroads of thrombosis and the innate immune response

Mirta Schattner1

  • 1Laboratory of Experimental Thrombosis, Institute of Experimental Medicine (IMEX-CONICET-National Academy of Medicine), Buenos Aires, Argentina.

Journal of Leukocyte Biology
|December 5, 2018
PubMed

Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.

Keywords:
HMGB-1TLRslpsnetsplateletssepsisthrombosis

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