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Long-term Depression01:05

Long-term Depression

33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:03

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
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Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

40.1K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
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Depressants01:28

Depressants

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Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
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Depression: Overview01:18

Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
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Updated: Feb 1, 2026

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

25.6K

[Postpartum depression].

Sarah Tebeka1, Caroline Dubertret1

  • 1Service de psychiatrie, hôpital Louis-Mourier, Colombes, France.

La Revue Du Praticien
|December 5, 2018
PubMed
Summary

Postpartum depression affects over 10% of women, impacting maternal health and child development. Early detection and management, including psychotherapy or antidepressants, are crucial for at-risk mothers.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Mental Health
  • Public Health

Background:

  • Postpartum depression (PPD) affects over 10% of women within a year of childbirth.
  • PPD has significant adverse effects on maternal well-being, including a high risk of recurrence, and negatively impacts child development.
  • The polymorphic symptoms of PPD can complicate diagnosis, with postpartum blues being a key differential diagnosis.

Purpose of the Study:

  • To highlight the public health significance of postpartum depression.
  • To emphasize the need for understanding PPD determinants for early, targeted interventions.
  • To underscore the importance of collegial management for mitigating adverse maternal and child outcomes.

Main Methods:

  • This abstract discusses the characteristics, diagnosis, and management of postpartum depression.
Keywords:
Couches pathologiques

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  • It reviews the multifactorial nature of the condition.
  • It outlines the necessity of understanding risk factors for prevention and effective treatment strategies.

    • Main Results:

    • Postpartum depression presents a major public health challenge with significant consequences.
    • Early identification of at-risk individuals is essential for prevention.
    • Effective management requires a collaborative approach, potentially including psychotherapy and/or antidepressant therapy.

    Conclusions:

    • Postpartum depression is a common and serious condition requiring comprehensive management.
    • Understanding its multifactorial determinants is key to developing effective prevention strategies.
    • Timely and appropriate interventions, including psychotherapy and pharmacotherapy, are vital for improving outcomes for both mother and child.