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Updated: Feb 1, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
[Lung cancer: epidemiology and screening]
Claire Merveilleux du Vignaux1, Sophie Beaucaire-Danel2, Nicolas Girard1
1Service de pneumologie, hôpital Louis-Pradel, groupement hospitalier Est, Lyon (Bron), France.
Lung cancer incidence is high, with tobacco smoking as a primary risk factor. Early diagnosis significantly improves survival, prompting discussions on screening opportunities for smokers.
Area of Science:
- Oncology
- Public Health
- Epidemiology
Background:
- Lung cancer is a leading cause of cancer incidence and mortality in France.
- The epidemiology of lung cancer is evolving, influenced by therapeutic advancements and risk factors like tobacco smoking.
- A significant proportion of lung cancer cases are diagnosed at a metastatic stage, limiting treatment efficacy and survival.
Purpose of the Study:
- To provide an overview of lung cancer epidemiology in France.
- To highlight the impact of early diagnosis and therapeutic innovations on lung cancer outcomes.
- To discuss the potential benefits of implementing screening programs for high-risk populations, particularly smokers.
Main Methods:
- Epidemiological data analysis for lung cancer incidence in France.
- Review of current therapeutic strategies and their impact on mortality.
- Assessment of survival rates based on diagnostic stage (early vs. metastatic).
Main Results:
- An estimated 39,495 lung cancer cases were recorded in France in 2012.
- Lung cancer ranks as the second most common cancer in men and third in women.
- Early-stage diagnosis, amenable to surgical resection, offers a 5-year survival rate exceeding 85%.
Conclusions:
- Lung cancer remains a significant public health concern in France.
- Therapeutic innovations are contributing to reduced mortality rates.
- The high survival rate for early-stage lung cancer underscores the importance of considering screening strategies for smokers.
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