Related Experiment Video
Updated: Feb 1, 2026
Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Specific features of childhood-onset inflammatory bowel diseases
Hélène Garnierlengliné1, Bénédicte Pigneur1, Frank M Ruemmele1
1Université Paris-Descartes, Sorbonne Paris-Cité, AP-HP, hôpital Necker-Enfants malades service de gastroentérologie, hépatologie et nutrition pédiatriques, Paris, France.
Insights
Pediatric-onset inflammatory bowel diseases (PIBD) are rising and present with greater severity. Treatment includes exclusive enteral nutrition for Crohn's disease and varied approaches for ulcerative colitis, with surgery often needed earlier in PIBD.
Area of Science:
- Gastroenterology
- Pediatrics
- Immunology
Context:
- The incidence of pediatric-onset inflammatory bowel diseases (PIBD) is increasing globally.
- PIBD is associated with higher disease activity and longer duration compared to adult-onset IBD.
- IBD encompasses Crohn's disease (CD) and ulcerative colitis (UC), with distinct gastrointestinal involvements.
Purpose:
- To outline the specific characteristics and management strategies for childhood-onset inflammatory bowel diseases.
- To highlight the differences in disease presentation and treatment pathways between pediatric and adult IBD patients.
Summary:
- Exclusive enteral nutrition is the primary induction therapy for luminal CD, promoting remission and healing.
- Management of UC varies by severity, with salicylates for mild-to-moderate cases and thiopurines or biologics for severe forms.
- Immunosuppressive and biologic therapies are crucial for maintenance, with surgery being a more frequent early intervention in PIBD.
Impact:
- Provides a comprehensive overview of PIBD, aiding clinicians in diagnosis and treatment selection.
- Emphasizes the importance of early and tailored interventions in improving outcomes for children with IBD.
- Contributes to the growing body of knowledge on pediatric inflammatory bowel diseases, informing future research and clinical guidelines.
Abstract:
Specific features of childhood-onset inflammatory bowel diseases. The incidence of pediatric-onset inflammatory bowel diseases (PIBD) is increasing in developed countries for several decades. Pediatric-onset of the disease is a factor of severity, due to a higher activity and a longer evolution of the disease. IBD presents as two major forms, Crohn's disease (CD) potentially affecting all parts of the gastrointestinal tract, and ulcerative colitis (UC), which is restricted to the colon and rectum. Exclusive enteral nutrition is the recommended first-choice induction therapy in luminal CD, allowing symptoms remission, mucosal healing and catch-up growth. The use of an immunosuppressive maintenance therapy is frequently required. Biological therapies may be used as first-line therapy in severe cases, or in case of failure of thiopurines. In mild to moderate forms of UC, salicylates retain an important role while the use of thiopurines or biological should be considered in severe forms of disease. The use of surgery is sometimes required, usually earlier in PIBD than in adult IBD patients.
More Related Videos
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are: