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[Clinical aspects and treatment of invasive meningococcal infections]

Perrine Parize1

  • 1Service des maladies infectieuses et tropicales, centre d'infectiologie, hôpital Necker, Paris, France.

La Revue Du Praticien
|December 5, 2018
PubMed

Insights

Invasive meningococcal infections can be severe, but early treatment improves outcomes. Meningococcal sepsis and purpura fulminans remain high-risk, necessitating updated diagnostic and management strategies.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Meningococcus is a common human bacterium residing in the upper respiratory tract.
  • Invasive meningococcal infections can lead to severe diseases, including sepsis and purpura fulminans.
  • While overall mortality has decreased due to medical advancements, case fatality for severe forms remains high.

Purpose of the Study:

  • To detail diagnostic strategies for suspected meningococcal disease.
  • To outline current management approaches for invasive meningococcal infections.
  • To summarize French Public Health Department guidelines on chemoprophylaxis and cluster management.

Main Methods:

  • Review of clinical aspects and treatment of invasive meningococcal infections.
  • Analysis of diagnostic and management protocols.
  • Summary of updated public health guidelines.

Main Results:

  • Antimicrobial agents, intensive care, and pre-admission antibiotics have reduced overall mortality.
  • Meningococcal sepsis and purpura fulminans continue to present high, stable case fatality rates.
  • Severe neurological and functional sequelae are common in survivors.

Conclusions:

  • Prompt diagnosis and management are crucial for improving outcomes in meningococcal disease.
  • Despite advances, severe forms of meningococcal infection pose significant risks.
  • Adherence to updated guidelines for chemoprophylaxis and cluster management is essential for public health.
Keywords:
Infections invasives à méningocoques

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