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Pregnancy and lactation in women with epilepsy
Sophie Dupont1,2,3,4
1Epilepsy Unit, hôpital de La Pitié-Salpêtrière, AP-HP, Paris, France.
Abstract:
Pregnancy and lactation in women with epilepsy. The establishment of prospective pregnancy registries in the late 1990s provided reliable and complementary information on the teratogenicity of antiepileptic drugs. Antiepileptic therapy increases the risk of fetal malformations significantly, specifically certain molecules as sodium valproate. The current uncertainty concerns the cognitive fate of children born to epileptic mothers treated during pregnancy: the use of sodium valproate is significantly associated with less good cognitive development and increased autistic risk, but little data are available on the other antiepileptic drugs, although the preliminary data are reassuring. The choice of antiepileptic treatment during pregnancy remains individual according to our current knowledge and to the patient by always weighing the pros and cons between the risk of fetal malformation and that of exacerbation of epilepsy.
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