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Updated: Feb 1, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
[Multidrug resistant bacteria and emerging antibiotic resistance traits]
Agnès B Jousset1, Laurent Dortet1, Thierry Naas1
1Centre national de référence associé de la résistance aux antibiotiques : entérobactéries productrices de carbapénémases, Le Kremlin-Bicêtre, France. EA7361, université Paris-Sud, université Paris-Saclay, LabEx Lermit, service de bactériologiehygiène, AP-HP, hôpital Bicêtre, Le Kremlin-Bicêtre, France. Evolution and Ecology of Resistance to Antibiotics Unit, Institut Pasteur- AP-HP-université Paris Sud, Paris, France.
Abstract:
Multidrug resistant bacteria and emerging antibiotic resistance traits. Since the 1990s, the dissemination of extended spectrum β-lactamase producing-Enterobacteriaceae that are resistant to a wide variety of common antimicrobials is serious global health concern. Carbapenems have rapidly become the treatment of choice of severe infections due to ESBL-producing Enterobacteriaceae, but carbapenem- resistant Enterobacteriaceae have been increasingly reported in France and worldwide. These bacteria are mainly found in feacal carriage but the number of clinically-relevant infections is increasing. In that context, we observe a renewed interest for old drugs like temocillin, tigecyclin or polymyxins. When susceptible, aminoglycosides are also often used to treat infections due to multiresistant bacteria. Unfortunately, in addition to significant risks of toxicity, the use of these last resort drugs can be compromised due to the emergence of new mechanisms of resistance.
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