Related Experiment Video
Updated: Feb 1, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation
Zhong-Zhu Chen1, Shi-Qiang Li1, Ya-Jun Zhang1
1Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI , Chongqing University of Arts and Sciences . 319 Honghe Avenue , Yongchuan , Chongqing 402160 , China.
Abstract:
A novel three-component cascade reaction was discovered and developed to synthesize pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles was prepared by means of the mild reaction and simple operation procedure, which could be applicable to a broad scope of functional aldehydes. Screening demonstrated that compound 5g exhibited a good potency in HCT116 cell lines, and this work validated the feasibility of this novel reaction for generating promising bioactive compounds.
More Related Videos
14:11Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
12:43The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique
Published on: November 28, 2016
Related Concept Videos
Intracellular Signaling Cascades
Aldol Condensation vs Claisen Condensation
Rab Cascades
Phase Transitions: Vaporization and Condensation
Amplifying Signals via Enzymatic Cascade
MAPK Signaling Cascades