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Updated: Feb 1, 2026

Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins
Published on: April 27, 2019
Rhabdoviruses, Antiviral Defense, and SUMO Pathway
Faten El Asmi1, Carlos Eduardo Brantis-de-Carvalho2, Danielle Blondel3
1INSERM UMR-S 1124, Université Paris Descartes, 75006 Paris, France. elasmi.faten@gmail.com.
Abstract:
Small Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity. In human, five paralogs of SUMO are known of which three are ubiquitously expressed (SUMO1, 2, and 3). Infection by rhabdoviruses triggers cellular responses through the activation of pattern recognition receptors, which leads to the production and secretion of interferon. This review will focus on the effects of the stable expression of the different SUMO paralogs or Ubc9 depletion on rhabdoviruses-induced interferon production and interferon signaling pathways as well as on the expression and functions of restriction factors conferring the resistance to rhabdoviruses.
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