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Published on: June 11, 2015
The precise molecular signals that control endothelial cell-cell adhesion within the vessel wall
Lilian Schimmel1, Emma Gordon2
1Institute for Molecular Bioscience, Genomics of Development and Disease Division, The University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia.
Abstract:
Endothelial cell-cell adhesion within the wall of the vasculature controls a range of physiological processes, such as growth, integrity and barrier function. The adhesive properties of endothelial cells are tightly controlled by a complex cascade of signals transmitted from the surrounding environment or from within the cells themselves, with the dynamic nature of cellular adhesion and the regulating signalling networks now beginning to be appreciated. Here, we summarise the current knowledge of the mechanisms controlling endothelial cell-cell adhesion in the developing and mature blood vasculature.
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