Related Experiment Video

Updated: Feb 1, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

15.5K

Red Blood Cell Alloimmunization in Multitransfused Pediatric Population in a Tertiary Care Hospital

A P Poornima1, Shiffi Fazal2, P S Shaiji2

  • 1Department of Transfusion Medicine, Government Medical College, Thiruvananthapuram, Kerala, 695011, India. drpoornimaap@gmail.com.

Indian Journal of Pediatrics
|December 6, 2018
PubMed

Insights

Red blood cell (RBC) alloimmunization affects 6.35% of pediatric patients receiving multiple transfusions, primarily against Rh antigens. Early first transfusion may reduce alloimmunization risk.

Area of Science:

  • Hematology
  • Immunology
  • Transfusion Medicine

Background:

  • Red blood cell (RBC) alloimmunization is a known complication in patients requiring multiple transfusions.
  • Understanding the prevalence and specificities of alloantibodies is crucial for managing transfusion reactions.

Purpose of the Study:

  • To determine the prevalence and specificity patterns of RBC alloimmunization in pediatric patients undergoing multiple transfusions.
  • To identify patient-related factors associated with the development of RBC alloimmunization.

Main Methods:

  • A descriptive cross-sectional study was conducted over two years.
  • Clinical data from multitransfused pediatric patients were collected.
  • RBC antibody screening and identification were performed, followed by analysis of patient factors.

Main Results:

  • RBC alloantibodies were detected in 6.35% (4/63) of patients; one patient (1.59%) had an autoantibody.
  • Identified alloantibodies were against Rh antigens: anti-E, anti-c, anti-Cw, and anti-D + anti-C.
  • A significant association was found between alloimmunization and receiving the first transfusion after two years of age.

Conclusions:

  • RBC alloimmunization against Rh antigens is a significant concern in multitransfused children.
  • Extended RBC phenotyping for Rh antigens and providing antigen-matched RBCs are recommended for children with ongoing transfusion needs.
Abstract

Keywords:
AlloantibodiesMultitransfusedPediatric populationRBC alloimmunization

More Related Videos

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

577
Assaying Blood Cell Populations of the Drosophila melanogaster Larva11:15

Assaying Blood Cell Populations of the Drosophila melanogaster Larva

Published on: November 11, 2015

12.9K

Related Concept Videos

Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
1.2K
Hospitals-I01:28

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.6K
Tertiary Healthcare System01:21

Tertiary Healthcare System

Specialized care provided over an extended period is called tertiary care. Usually, a primary or secondary care physician will refer a patient to tertiary care. A patient's maximum physical and mental function is restored in tertiary care, which is caused due to the impact of a chronic illness or condition. Tertiary care aims to achieve the highest level of functioning possible while managing chronic illness. For example, a patient who falls and fractures their hip will need secondary care...
2.2K
What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.7K
Nomenclature of Secondary and Tertiary Amines01:12

Nomenclature of Secondary and Tertiary Amines

The secondary and tertiary amines are derivatives of ammonia, where two and three of its hydrogens are replaced by alkyl groups, respectively. Secondary and tertiary amines can be symmetrical with identical alkyl groups attached to the nitrogen atom or unsymmetrical when more than one type of alkyl group is present. The standard nomenclature of secondary and tertiary amines is similar to the names given to the primary amines. They are generally named alkylamines. As depicted in Figure 1, for...
5.2K
Conservation of Small Populations02:04

Conservation of Small Populations

Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.3K