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Updated: Feb 1, 2026
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
THE INFLUENCE OF SODIUM SALTS OF CARBOXYMETHYLATES OF OXYETHYLATED ISONONYLPHENOLS ON THE NEUTRALIZING FUNCTION OF
D Marakushyn1, I Karmazina1, I Isaeva1
1Kharkiv National Medical University, Ukraine.
Abstract:
The study was conducted as a part of research work "Biochemical mechanisms of the development of dismetabolic processes under the influence of chemical environmental factors". The purpose of the present work was to study the effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment and to reveal a potential danger for homoitherms and human beings. The object of the study were the white rats of WAG population. The effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols of such brands as AFS 9-4 КМ, AFS 9-6 КМ, AFS 9-10 КМ on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment were studied. It was set that studied compounds during their subacute influence in a toxicological experiment stimulated the hydroxyling microsomal monooxygenase system of hepatocytes and inhibited reactions of the formation of glucuronid and glutathione conjugations against a background of more active processes of the formation of acetyl conjugation, higher levels in the content of CoA-SH, acetyl-CoA and ketone bodies.
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