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Updated: Feb 1, 2026
07:07
Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
Published on: May 2, 2017
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Diffuse Large B-Cell Lymphoma Recurring as Neurolymphomatosis on FDG PET/CT
Rueben Ganeshalingam1, Paul Roach, Geoffrey Paul Schembri
1From the Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia.
Clinical Nuclear Medicine
|December 6, 2018
Summary
Neurolymphomatosis, a rare relapse of diffuse large B-cell lymphoma, can be diagnosed using FDG PET/CT. This imaging technique detected nerve involvement in two patients, highlighting its utility in identifying uncommon lymphoma recurrence sites.
Area of Science:
- Oncology
- Nuclear Medicine
- Neurology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Neurolymphomatosis is a rare manifestation of lymphoma relapse involving peripheral nerves.
- Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) is a key imaging modality in lymphoma management.
Observation:
- Two patients with a history of DLBCL presented with symptoms suggestive of relapse.
- Initial chemotherapy resulted in a complete metabolic response in both patients.
- Recurrence manifested as neurolymphomatosis, affecting peripheral nerves and the spinal cord.
Findings:
- FDG PET/CT revealed intense radiotracer uptake in the sciatic nerves of Patient 1, confirmed by biopsy.
- FDG PET/CT identified relapse in the spinal cord, sciatic nerve, and facial nerves in Patient 2.
- Neurolymphomatosis represented the sole site of relapse in both cases, an uncommon FDG PET/CT finding.
Implications:
- FDG PET/CT can detect neurolymphomatosis, an uncommon site of DLBCL relapse.
- This imaging modality aids in the early diagnosis and management of nerve-involved lymphoma recurrence.
- Awareness of neurolymphomatosis on FDG PET/CT is crucial for oncologists and nuclear medicine physicians.
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