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Human papillomaviruses' proteins with clinical utility
Alina Fudulu1, Adrian Albulescu1,2, Gabriela Anton1
1a Department of Molecular Virology , Stefan S Nicolau Institute of Virology , Bucharest , Romania.
Journal of Immunoassay & Immunochemistry
|December 7, 2018
Summary
Cervical cancer remains a global threat despite HPV vaccination and screening. New diagnostic tools focusing on human papilloma virus (HPV) proteins are needed for early detection and risk assessment.
Area of Science:
- Oncology
- Virology
- Public Health
Background:
- Cervical cancer is a major global cause of cancer deaths in women.
- Human papilloma virus (HPV) infection is a primary cause of cervical cancer.
- Despite vaccination and screening, cervical cancer incidence is projected to rise.
Purpose of the Study:
- To highlight the need for advanced diagnostic tools for genital HPV infection.
- To explore the potential of HPV viral proteins as diagnostic markers.
- To investigate HPV proteins for early detection and risk assessment of cervical cancer.
Main Methods:
- Review of current diagnostic strategies for HPV infection.
- Analysis of the role of HPV viral proteins in disease progression.
- Exploration of combining HPV protein detection with other biomarkers.
Main Results:
- Current screening methods may not be sufficient to curb rising cervical cancer rates.
- HPV viral proteins show promise as potential diagnostic or screening tools.
- Integration of HPV protein detection with cellular markers, HPV DNA, or PAP tests could improve accuracy.
Conclusions:
- There is an urgent need for improved diagnostic methods for HPV infections.
- HPV viral protein expression warrants further investigation for clinical application.
- Developing novel diagnostic tools is crucial to combat the increasing burden of cervical cancer.