[HPV self-sampling for cervical cancer screening in Denmark]

Area of Science:

• Oncology
• Public Health
• Gynecology

Background:

• Cervical cancer screening non-participation disproportionately affects underscreened women, representing 45% of incident cases in Denmark.
• Human papillomavirus (HPV) self-sampling demonstrates higher efficacy in engaging non-participants compared to traditional physician-based screening.
• Previous studies indicate good adherence to follow-up protocols among individuals testing positive via HPV self-sampling.

Purpose of the Study:

• To evaluate the effectiveness of HPV self-sampling in reaching underscreened populations for cervical cancer screening.
• To assess the potential of HPV self-sampling to improve cervical cancer prevention strategies in Denmark.

Main Methods:

• Review of evidence supporting HPV self-sampling over physician-based screening for non-participants.
• Analysis of reported compliance rates for follow-up among HPV-positive self-samplers.
• Examination of new Danish cervical cancer screening guidelines recommending HPV self-sampling for specific cohorts.

Main Results:

• HPV self-sampling is a superior method for engaging women who are un- or underscreened for cervical cancer.
• High compliance with follow-up procedures has been observed in women who self-collected samples and tested HPV-positive.
• The updated Danish guidelines incorporate HPV self-sampling to target women due for their second screening reminder.

Conclusions:

• HPV self-sampling represents a key strategy to improve cervical cancer prevention by increasing screening uptake in underserved populations.
• The integration of HPV self-sampling into national guidelines is a proactive measure to reduce the burden of cervical cancer.
• Targeting women with second screening reminders via HPV self-sampling offers a promising avenue for enhanced public health outcomes.