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Updated: Feb 1, 2026
Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
Published on: April 1, 2019
Association between brown adipose tissue and bone mineral density in humans
Guillermo Sanchez-Delgado1, Borja Martinez-Tellez2,3, Yolanda Garcia-Rivero4,5
1PROFITH "PROmoting FITness and Health through physical activity" research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain. gsanchezdelgado@ugr.es.
Background:
Brown adipose tissue (BAT) seems to play a role in bone morphogenesis. A negative association has been reported between BAT and bone mineral density (BMD) in women, but not in men. A panel of experts has recently published a set of recommendations for BAT assessment, and thus, to re-address previously reported associations is needed. This study aimed to investigate the association between cold-induced BAT 18F-Fluorodeoxyglucose (18F-FDG) uptake and BMD in young healthy adults.
Methods:
Ninety-eight healthy adults (68 women; 22 ± 2.2 years old; 24.3 ± 4.5 kg/m2) cold-induced BAT was assessed by means of an 18F-FDG positron emission tomography-computed tomography (PET-CT) scan preceded by a personalized cold stimulation. The cold exposure consisted in 2 h in a mild cold room at 19.5-20 °C wearing a water perfused cooling vest set 4 °C above the individual shivering threshold. Total body and lumbar spine BMD were assessed by a whole-body DXA scan.
Results:
We found no association between BMD and cold-induced BAT volume, mean, and maximal activity (all P > 0.1) in neither young and healthy men nor women. These results remained unchanged when adjusting by height, by body composition, and by objectively assessed physical activity. Sensitivity analyses using the criteria to quantify cold-induced BAT-related parameters applied in previous studies did not change the results.
Conclusions:
In summary, our study shows that there is no association between cold-induced BAT and BMD in young healthy adults. Moreover, our data support the notion that previously shown associations between BAT and BMD in healthy non-calorically restricted individuals, could be driven by methodological issues related to BAT assessment and/or sample size limitations.
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