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[Immunoadsorption in dermatology].

Franziska Hübner1, Michael Kasperkiewicz1, Detlef Zillikens1

  • 1Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|December 7, 2018
PubMed
Summary
This summary is machine-generated.

Immunoadsorption (IA) removes pathogenic autoantibodies in autoimmune bullous diseases like pemphigus and pemphigoid. This therapy shows promise for severe atopic dermatitis, with future potential for antigen-specific antibody reduction.

Keywords:
Atopic dermatitisAutoantibodiesAutoimmune dermatosesPemphigoidPemphigus

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Autoimmune bullous diseases involve autoantibodies targeting skin and mucous membrane components.
  • Immunoadsorption (IA) is an established method for antibody removal, used in other medical fields.

Purpose of the Study:

  • To review the use of immunoadsorption (IA) as an adjuvant therapy in dermatology.
  • To explore IA applications in pemphigus, pemphigoid diseases, and atopic dermatitis.

Main Methods:

  • Review of existing data on IA use in dermatological conditions.
  • Discussion of different IA protocols, including pan-immunoglobulin and IgE-specific adsorbers.

Main Results:

  • IA is primarily used for severe/refractory pemphigus vulgaris, pemphigus foliaceus, and pemphigoid diseases.
  • Emerging data supports IA protocols for severe atopic dermatitis with high IgE levels.

Conclusions:

  • Immunoadsorption is a viable therapeutic option for autoimmune bullous diseases and severe atopic dermatitis.
  • Future developments may include antigen-specific adsorbers for targeted autoantibody reduction.