Vertebral fractures cascade: potential causes and risk factors
1Rheumatology Department, CHU Lapeyronie Montpellier, 371 avenue du Gaston Giraud, 34090, Montpellier, France. che.helene@yahoo.fr.
Summary
Vertebral fracture cascade (VFC) is a severe event in osteoporosis. This study found that only half of VFC cases were linked to secondary osteoporosis, highlighting the need for further research into its causes.
Area of Science:
- Bone Biology and Osteoporosis Research
- Clinical Medicine and Geriatrics
Background:
- Vertebral fracture (VF) is the most common osteoporotic fracture.
- Subsequent VFs significantly increase the risk of vertebral fracture cascade (VFC).
- Identifying causes and risk factors for VFC is crucial for patient management.
Purpose of the Study:
- To investigate potential causes and risk factors contributing to vertebral fracture cascade (VFC).
- To analyze the prevalence of secondary osteoporosis in patients experiencing VFC.
Main Methods:
- Retrospective collection of VFC cases between January 2016 and April 2017.
- Definition of VFC as at least three VFs within a one-year period.
- Inclusion of 113 patients from 10 centers.
Main Results:
- 54% of VFC cases were attributed to postmenopausal osteoporosis.
- Secondary osteoporosis was diagnosed in 52 patients, with glucocorticoid-induced osteoporosis being the most common (25.7%).
- 11.8% of VFC cases occurred post-vertebroplasty, and 31.5% of patients had prior anti-osteoporotic treatment.
Conclusions:
- Only about half of vertebral fracture cascade (VFC) cases were associated with a secondary cause of osteoporosis.
- Further prospective studies are required to fully understand the determinants of VFC.
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