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Synthesis of Keratin-based Nanofiber for Biomedical Engineering
Published on: February 7, 2016
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Cell laden alginate-keratin based composite microcapsules containing bioactive glass for tissue engineering
Supachai Reakasame1, Daniela Trapani1, Rainer Detsch1
1Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstr.6, 91058, Erlangen, Germany.
Journal of Materials Science. Materials in Medicine
|December 7, 2018
Summary
New alginate-keratin microcapsules, including those with bioactive glass, show promise for tissue engineering. Modified alginate enhanced degradation, while bioactive glass improved bone regeneration potential.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Alginate-keratin microcapsules are explored for biomedical applications.
- Modifications like dialdehyde (ADA) and bioactive glass (BG) can enhance material properties.
Purpose of the Study:
- To prepare and characterize alginate-keratin, ADA-keratin, and ADA-keratin-BG microcapsules.
- To evaluate the degradation, bioactivity, and cellular response of these microcapsules.
- To assess their potential for cell-laden biofabrication.
Main Methods:
- Microcapsule preparation using alginate, keratin, ADA, and 45S5 bioactive glass.
- Characterization via light microscopy, SEM, and FTIR.
- In vitro evaluation of cell viability and calcium phosphate (CaP) formation with MG-63 cells.
Main Results:
- ADA-based microcapsules exhibited faster degradation than alginate-based ones.
- Incorporation of BG particles (2.0 µm) enhanced material bioactivity.
- Cell viability increased over 21 days in all microcapsules.
- BG-containing samples showed CaP formation after 3 weeks, indicating bioactivity.
Conclusions:
- ADA-keratin and ADA-keratin-BG microcapsules offer tunable degradation and improved bioactivity.
- While initial BG incorporation may slightly affect cell growth, it promotes mineralization.
- These materials are suitable for developing cell-laden bioinks for biofabrication.
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