Electrophysiologic evaluation of antiarrhythmic therapy for ventricular tachyarrhythmias

The use of electrophysiologic studies has contributed significantly to our understanding of the mechanisms of ventricular tachyarrhythmias and enhanced our ability to assess objectively the efficacy of various therapeutic interventions in modifying or preventing their recurrence. The basis on which electrophysiologic testing techniques is founded is the ability reproducibility to initiate ventricular arrhythmias by programmed electrical stimulation in patients with a history of recurrent ventricular tachycardia or fibrillation. Ventricular tachycardia can be initiated by electrophysiologic studies in approximately 90% of patients with clinically documented recurrent, sustained ventricular tachycardia related to coronary artery disease and in 60% of patients with nonsustained ventricular tachycardia. Reports indicate that electrophysiologic testing is highly specific as well (99% for sustained monomorphic ventricular tachycardia). Studies in patients with recurrent ventricular tachycardia demonstrate that prevention by antiarrhythmic drugs of the ability to initiate tachycardias that were previously inducible by comparable stimulation techniques in the absence of therapy is highly predictive of freedom from recurrent episodes of spontaneous ventricular tachycardia and ventricular fibrillation. This end point can be achieved in 35 to 75% of patients. This wide range of success rates results from differences in the patient populations studied, as well as major differences in the programmed stimulation and antiarrhythmic drug protocols used among laboratories. The positive predictive value of this technique (defined as the percentage of patients in whom complete suppression of inducible ventricular tachycardia or ventricular fibrillation is achieved during electrophysiologic testing with antiarrhythmic drugs and in whom no spontaneous arrhythmia occurs at 1- to 2-year follow-up) ranges between 80 and 95%.