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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Psychosis in neurodegenerative disorders: recent developments.

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This review highlights recent advances in understanding psychosis in neurodegenerative disorders, focusing on sex differences, biomarkers, shared mechanisms with schizophrenia, and new therapeutic strategies for dementia-related psychosis.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Gerontology

Background:

  • Psychosis is a significant non-motor symptom in various neurodegenerative disorders.
  • Understanding the underlying mechanisms and effective treatments for psychosis in this population is crucial.

Purpose of the Study:

  • To review the latest literature on psychosis in neurodegenerative disorders.
  • To discuss emerging research directions and therapeutic advancements.

Main Methods:

  • Literature review of recent findings.
  • Synthesis of information on key themes in the field.

Main Results:

  • Recent research emphasizes the influence of sex on psychosis expression in neurodegenerative conditions.
  • The relationship between psychosis and neurodegenerative disease biomarkers is a key area of investigation.
  • Shared mechanisms between psychosis in neurodegenerative disorders and primary psychotic disorders like schizophrenia are being explored.
  • Promising therapeutic developments, including novel treatments, are emerging for dementia-related psychosis.

Conclusions:

  • Future research should continue to explore sex-specific effects, refine biomarker identification, and investigate shared pathways with other psychiatric disorders.
  • Advancements in therapeutics offer new hope for managing psychosis in patients with neurodegenerative diseases.