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Related Experiment Videos

Differences in diagnostic test results and hematologic data between aged and young horses.

S L Ralston1, C F Nockels, E L Squires

  • 1Department of Clinical Sciences, Colorado State University, Fort Collins 80523.

American Journal of Veterinary Research
|August 1, 1988
PubMed
Summary

Aging in horses is associated with changes in blood counts and metabolic responses. Aged horses showed higher mean corpuscular volume and lower ascorbic acid, with a link between adenomas and hyperinsulinemia.

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Area of Science:

  • Veterinary Medicine
  • Equine Science
  • Animal Physiology

Background:

  • Aging in horses can lead to physiological changes.
  • Understanding these changes is crucial for equine health management.
  • Previous studies have not comprehensively evaluated hematologic and metabolic shifts in aged horses.

Purpose of the Study:

  • To identify hematologic and metabolic alterations in aged horses compared to young horses.
  • To investigate the relationship between aging, glucose metabolism, and endocrine function in horses.
  • To determine the prevalence of adenomas in aged horses and their association with metabolic changes.

Main Methods:

  • Comparative analysis of complete blood counts and serum biochemical profiles in young and aged horses.

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  • Oral glucose tolerance tests and insulin response measurements.
  • Dexamethasone suppression tests (DST) and necropsies on aged horses.

    • Main Results:

    • Aged horses exhibited a higher mean corpuscular volume and lower plasma ascorbic acid levels.
    • A hyperinsulinemic response to glucose was observed in aged horses, strongly associated with subclinical hypophyseal and/or thyroid adenomas.
    • Necropsies revealed adenomas in 10 out of 13 aged horses.

    Conclusions:

    • Aging in horses is characterized by specific hematologic and metabolic changes.
    • Subclinical hypophyseal and/or thyroid adenomas are common in aged horses and linked to glucose metabolism dysfunction.
    • These findings highlight the importance of considering age-related endocrine and metabolic conditions in equine diagnostics.