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Related Experiment Video

Updated: Feb 1, 2026

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

An update: emerging drugs for tinnitus.

Christopher R Cederroth¹, Jonas Dyhrfjeld-Johnsen², Berthold Langguth^3,4

¹a Department of Physiology and Pharmacology , Karolinska Institutet , Stockholm , Sweden.

Expert Opinion on Emerging Drugs

|December 8, 2018

Summary

Despite advances in understanding tinnitus, drug development remains challenging. This review examines promising drug candidates and discusses improving future research for tinnitus treatments.

Keywords:

Tinnitus auditory system hearing hidden hearing loss meta-analysis pharmacotherapy systematic review treatment

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Area of Science:

Neuroscience
Pharmacology
Otolaryngology

Background:

Tinnitus affects millions, with limited pharmacologic treatments despite recent progress in understanding its pathophysiology.
Novel drug targets for tinnitus are emerging, yet clinical interventions remain scarce.

Purpose of the Study:

To review recent clinical trial results for novel tinnitus drug candidates.
To reevaluate the translational development approach from animal models to human trials.
To discuss and improve future research and development (R&D) for tinnitus therapies.

Main Methods:

Discussion of Phase 3 and Phase 2a trial data for AM-101 (NMDA receptor antagonist).
Review of Phase 2a trial data for BGG492 (AMPA receptor antagonist).
Examination of early-stage trial data for AUT00063 (Kv3 modulator).

Main Results:

Clinical trial outcomes for AM-101, BGG492, and AUT00063 are presented and discussed.
The translational validity of animal models in predicting human tinnitus treatment efficacy is critically assessed.
Current challenges in tinnitus drug development, including high-risk factors, are highlighted.

Conclusions:

Pharmaceutical research for tinnitus is high-risk despite pathophysiologic knowledge gains.
Future R&D requires better identification of therapeutic targets and objective outcome measures.
Improving translational research is crucial for advancing tinnitus pharmacotherapeutics.