Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

3.7K
3.7K
Improving Translational Accuracy02:07

Improving Translational Accuracy

14.9K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.9K
Bone Structure01:55

Bone Structure

51.7K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.7K
Bone Remodeling01:40

Bone Remodeling

40.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.4K
Compact Bone01:27

Compact Bone

16.5K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.5K
Bone Disorders01:29

Bone Disorders

5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sustained Decrease in Oxygen Saturation in Human Fibular Fractures Monitored with Laser-Doppler and White-Light Spectroscopy: A Longitudinal Observational Pilot Study.

Journal of functional biomaterials·2026
Same author

The cortisol stress response following surgery for proximal femur fractures in geriatric patients - a prospective pilot study.

Frontiers in endocrinology·2026
Same author

[Are you Alright? - Well-being, Stress and Surgical Training].

Zentralblatt fur Chirurgie·2026
Same author

The arc-technique using a photodynamic nail in a dysmorphic fragility fracture of the posterior pelvic ring - a technical note & case report.

Trauma case reports·2026
Same author

Augmented stabilization of a rare geriatric "open book"-injury, using a cement augmented internal fixator - a case report.

Trauma case reports·2026
Same author

War injuries and antimicrobial resistance: what impact do multi-resistant pathogens have on the treatment of Ukrainian war- wounded patients?

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026

Related Experiment Video

Updated: Feb 1, 2026

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
07:41

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice

Published on: November 13, 2016

13.9K

Marble-derived microcalcite improves bone healing in mice osteotomy.

Marcel Orth1,2, Takhirjan Shadmanov2, Claudia Scheuer2

  • 1Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany.

Biomedical Materials (Bristol, England)
|December 8, 2018
PubMed
Summary

Microcalcite (MCA) combined with platelet-rich plasma (PRP) shows promise for enhancing bone healing. This novel biomaterial combination accelerated fracture repair and improved bone stability in a mouse model.

More Related Videos

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
05:53

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing

Published on: August 16, 2018

16.2K
In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur
07:33

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

Published on: November 14, 2017

10.0K

Related Experiment Videos

Last Updated: Feb 1, 2026

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
07:41

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice

Published on: November 13, 2016

13.9K
The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
05:53

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing

Published on: August 16, 2018

16.2K
In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur
07:33

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

Published on: November 14, 2017

10.0K

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Regenerative Medicine

Background:

  • Delayed bone healing and non-unions affect approximately 10% of fractures.
  • Osteoconductive and osteoinductive biomaterials can improve bone healing.
  • Microcalcite (MCA), a calcium carbonate biomaterial, presents potential for bone regeneration.

Purpose of the Study:

  • To investigate the efficacy of microcalcite-loaded platelet-rich plasma (MCA + PRP) as a bone graft material.
  • To evaluate the impact of MCA + PRP on bone healing in a murine osteotomy model.

Main Methods:

  • Osteotomies were created in CD-1 mice, with groups receiving MCA + PRP, PRP alone, or no treatment.
  • Bone healing was assessed at 2 and 5 weeks using micro-computed tomography (μCT), histomorphometry, immunohistochemistry, and Western Blotting.

Main Results:

  • MCA + PRP treatment significantly increased bone volume and biomechanical stability compared to controls.
  • Histomorphometry indicated accelerated bone healing and remodeling, with a higher osseous tissue fraction in the MCA + PRP group.
  • Immunohistochemistry revealed increased cell proliferation (Ki67+ cells), and Western Blotting showed a modified expression of bone morphogenetic proteins.

Conclusions:

  • MCA combined with PRP effectively promotes bone healing in a murine model.
  • This combination may serve as a promising novel bone graft material for clinical applications in fracture treatment.