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[Anaphylactic shock].

E Bavoux1, F J Baud

  • 1Réanimation toxicologique, Hôpital Fernand Widal, Université Paris.

Allergie Et Immunologie
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

Anaphylactic shock is a severe allergic reaction caused by mediator release. Prophylaxis is key, with adrenaline and fluids essential for treatment when it occurs.

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Area of Science:

  • Immunology
  • Pharmacology

Context:

  • Anaphylactic shock involves the release of active substances like histamine from mast cells and basophils.
  • Reactions can be immunologically mediated (IgE-dependent) or non-immunologically mediated.
  • Mediator release affects cardiovascular, respiratory, and skin systems.

Purpose:

  • To describe the mechanisms, triggers, and treatment of anaphylactic shock.

Summary:

  • Anaphylactic shock is a life-threatening systemic reaction due to mediator release (histamine, leukotrienes).
  • It can be triggered by IgE-mediated hypersensitivity or other processes.
  • Manifestations include vasodilation, bronchospasm, and urticaria.

Impact:

  • Understanding anaphylaxis is crucial for prompt diagnosis and management.
  • Prophylactic measures are vital due to common triggers like drugs and contrast media.
  • Adrenaline, fluid resuscitation, and bronchodilators are primary treatments for established anaphylaxis.