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Aging of mesenchymal stem cells: Implication in regenerative medicine
1Grove School of Engineering, The City University of New York - the City College, New York, NY 10031, USA.
Regenerative Therapy
|December 8, 2018
Summary
Aging impairs multipotent mesenchymal stem cells (MSCs), affecting their use in regenerative medicine. Understanding senescence-induced damage is crucial before applying MSCs for tissue or organ regeneration.
Area of Science:
- Stem cell biology
- Regenerative medicine
- Aging research
Background:
- Multipotent mesenchymal stem cells (MSCs) are promising for regenerative medicine.
- Cellular aging, both in vivo and in vitro, negatively impacts MSC function.
- MSC senescence poses challenges for therapeutic applications.
Purpose of the Study:
- To review current understanding of senescence-induced damage in MSCs.
- To highlight considerations for MSC-based regenerative therapies.
Main Methods:
- Literature review of senescence and MSCs.
- Analysis of aging effects on MSC characteristics.
- Synthesis of current research on MSC damage.
Main Results:
- Aging significantly compromises MSC characteristics and performance.
- Senescence leads to detrimental changes in MSCs.
- These changes impact their regenerative potential.
Conclusions:
- MSC senescence is a critical factor in regenerative medicine.
- Consideration of senescence-induced damage is essential for successful MSC application.
- Further research is needed to mitigate aging effects on MSCs.
Keywords:
AgingDifferentiationMSC, Mesenchymal stem cellMesenchymal stem cellNCPD, Number of cell population doublingProliferationRegenerative medicineSenescenceMore Related Videos
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