Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conserved Binding Sites01:49

Conserved Binding Sites

5.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.2K
Conserved Binding Sites01:49

Conserved Binding Sites

1.9K
1.9K
Ligand Binding Sites02:40

Ligand Binding Sites

15.1K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.1K
Ligand Binding Sites02:40

Ligand Binding Sites

8.8K
8.8K
Ionic Crystal Structures02:42

Ionic Crystal Structures

17.0K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
17.0K
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

5.0K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An acoustic platform for facile, size-targeted polymeric nanoparticle synthesis.

Chemical science·2026
Same author

Microwave-Driven Intensification of Diglycerol Transesterification through Dynamic Temperature Operation.

ACS sustainable chemistry & engineering·2026
Same author

Uniform annular cavitation field and superior mixing characteristics of a tube-in-tube continuous-flow ultrasonic reactor.

Ultrasonics·2026
Same author

Solubility and antisolvent crystallization of lithium hydroxide monohydrate in various organic solvents.

Physical chemistry chemical physics : PCCP·2026
Same author

Ultrasonic microreactor-mediated fabrication of stable W<sub>1</sub>/O/W<sub>2</sub> double emulsions for efficient vitamin C encapsulation.

Ultrasonics sonochemistry·2026
Same author

Synthesizing porous nanospheres with highly efficient drug loading and sustained release through a thermal-controlled continuous stirred-tank reactor cascade.

Nanoscale advances·2026

Related Experiment Video

Updated: Feb 1, 2026

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells
09:53

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells

Published on: December 31, 2009

12.7K

Microbubbles as Heterogeneous Nucleation Sites for Crystallization in Continuous Microfluidic Devices.

Naghmeh Fatemi1, Zhengya Dong1, Tom Van Gerven1

  • 1KU Leuven , Department of Chemical Engineering , 3001 Leuven , Belgium.

Langmuir : the ACS Journal of Surfaces and Colloids
|December 12, 2018
PubMed
Summary

Microbubbles enhance particle formation and continuous crystallization in microfluidic devices by promoting nucleation and preventing clogging. This method improves crystal yield and process efficiency.

More Related Videos

Thermal Measurement Techniques in Analytical Microfluidic Devices
08:29

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

10.1K
A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization
08:01

A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization

Published on: August 18, 2022

3.6K

Related Experiment Videos

Last Updated: Feb 1, 2026

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells
09:53

Automated Microfluidic Blood Lysis Protocol for Enrichment of Circulating Nucleated Cells

Published on: December 31, 2009

12.7K
Thermal Measurement Techniques in Analytical Microfluidic Devices
08:29

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

10.1K
A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization
08:01

A Microfluidic Approach for the Study of Ice and Clathrate Hydrate Crystallization

Published on: August 18, 2022

3.6K

Area of Science:

  • Chemical Engineering
  • Materials Science
  • Fluid Dynamics

Background:

  • Controlling particle formation in microfluidic devices is crucial for various applications.
  • Heterogeneous interfaces can influence nucleation and crystallization processes.
  • Microfluidic devices are susceptible to clogging, limiting continuous operation.

Purpose of the Study:

  • To investigate the use of microbubbles for enhancing nucleation and controlling particle formation in microfluidic devices.
  • To determine the optimal conditions for microbubble flow in a two-phase system.
  • To evaluate the impact of microbubbles on the continuous crystallization of paracetamol.

Main Methods:

  • Establishing a two-phase flow regime map by varying gas and liquid flow rates.
  • Studying the cooling crystallization of paracetamol in the presence of microbubbles.
  • Analyzing crystal yield and monitoring for reactor clogging.

Main Results:

  • Microbubbles significantly enhanced nucleation rates compared to bubble-free operation.
  • Increased crystal formation and reduced metastable zone width were observed.
  • Continuous crystallization of paracetamol was achieved without microreactor clogging, leading to higher crystal mass.

Conclusions:

  • Injecting microbubbles is an effective strategy for enhancing nucleation and controlling particle formation in microfluidic systems.
  • Microbubble-assisted crystallization allows for continuous operation and improved crystal yield.
  • This approach offers a solution to the clogging issue in microfluidic reactors.