Related Experiment Video
Updated: Feb 1, 2026
16:13
Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
Published on: June 13, 2011
20.4K
Cortical abnormalities in episodic migraine: A multi-center 3T MRI study
Stefano Magon1,2, Arne May3, Anne Stankewitz3,4
11 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.
Cephalalgia : an International Journal of Headache
|December 12, 2018
Summary
Migraine patients exhibit cortical thinning in specific brain areas compared to healthy individuals. These brain changes may be linked to genetic factors or the impact of repeated migraine attacks.
Area of Science:
- Neuroimaging
- Neurology
- Medical Research
Background:
- Previous studies on cortical thickness in migraine patients yielded inconsistent results.
- Small sample sizes in prior research may explain these discrepancies.
Purpose of the Study:
- Investigate cortical thickness differences between migraineurs and control subjects.
- Analyze a large cohort to identify specific brain regions affected by migraine.
Main Methods:
- Utilized 3 Tesla MRI data from 131 migraine patients and 115 controls.
- Applied vertex-wise linear modeling, controlling for age, gender, and scanner type.
- Examined the impact of clinical factors like attack frequency and disorder duration on cortical thickness.
Main Results:
- Migraineurs showed reduced cortical thickness in areas including the central sulcus, middle-frontal gyrus, and visual cortices.
- Cortical thinning correlated with migraine attack frequency and disorder duration.
- Distinct patterns of thinning were observed between patients with and without aura, affecting regions like the anterior cingulate and intraparietal sulcus.
Conclusions:
- Confirmed the presence of cortical abnormalities in specific brain regions among migraineurs.
- Suggested that observed abnormalities could stem from genetic predisposition or the cumulative effects of migraine attacks.
- Highlighted the potential of neuroimaging to reveal underlying brain changes in migraine.
More Related Videos
Related Concept Videos
01:14Imaging Studies I: CT and MRI
879
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
879
02:23Abnormal Proliferation
5.2K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
02:33Lattice Centering and Coordination Number
11.6K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
11.6K
00:58Center of Gravity
6.7K
The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.7K
01:15Center of Gravity
2.2K
The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
To determine its location, the principle of moments can be utilized by dividing the object into...
2.2K
00:59Center of Mass
2.0K
The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
2.0K