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Emerging Cellular Therapies for Cancer

Sonia Guedan1,2, Marco Ruella2,3,4, Carl H June2,3,4,5

  • 1Department of Hematology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain;

Annual Review of Immunology
|December 12, 2018
PubMed

Insights

Genetically engineered T cells, including Chimeric Antigen Receptor (CAR) T cells, represent a new frontier in cancer treatment. Advances in synthetic biology and cell engineering promise broader therapeutic applications beyond oncology.

Area of Science:

  • Immunology
  • Biotechnology
  • Oncology

Background:

  • Genetically engineered T cells are emerging as potent therapeutics for cancer.
  • Chimeric Antigen Receptor (CAR) T cell therapy has gained FDA approval for leukemia and lymphoma.
  • Engineered immune cells represent a novel class of cancer treatments.

Purpose of the Study:

  • To highlight the potential of genetically engineered T cells in medicine.
  • To discuss the role of synthetic biology in enhancing immune cell function.
  • To explore future applications of T cell-based therapies.

Main Methods:

  • Leveraging synthetic biology for cellular engineering.
  • Advancements in T cell engineering techniques.
  • Utilizing genetic editing for improved lymphocyte function.
  • Optimizing cell manufacturing processes.

Main Results:

  • CAR T cells demonstrate efficacy in treating leukemia and lymphoma.
  • Synthetic biology expands the toolkit for programming immune cells.
  • Engineered T cells offer hope for curative cancer responses.

Conclusions:

  • Genetically engineered T cells are a powerful new therapeutic modality.
  • Advances in T cell engineering and manufacturing will broaden applications.
  • T cell therapies hold promise beyond oncology, including infectious diseases, transplantation, and autoimmunity.
Keywords:
CAR-T celladoptive cell transferchimeric antigen receptorimmune-oncologyleukemiasynthetic biology

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