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Emerging Cellular Therapies for Cancer.
Sonia Guedan1,2, Marco Ruella2,3,4, Carl H June2,3,4,5
1Department of Hematology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain;
Annual Review of Immunology
|December 12, 2018
Summary
Genetically engineered T cells, including Chimeric Antigen Receptor (CAR) T cells, represent a new frontier in cancer treatment. Advances in synthetic biology and cell engineering promise broader therapeutic applications beyond oncology.
Area of Science:
- Immunology
- Biotechnology
- Oncology
Background:
- Genetically engineered T cells are emerging as potent therapeutics for cancer.
- Chimeric Antigen Receptor (CAR) T cell therapy has gained FDA approval for leukemia and lymphoma.
- Engineered immune cells represent a novel class of cancer treatments.
Purpose of the Study:
- To highlight the potential of genetically engineered T cells in medicine.
- To discuss the role of synthetic biology in enhancing immune cell function.
- To explore future applications of T cell-based therapies.
Main Methods:
- Leveraging synthetic biology for cellular engineering.
- Advancements in T cell engineering techniques.
- Utilizing genetic editing for improved lymphocyte function.
- Optimizing cell manufacturing processes.
Main Results:
- CAR T cells demonstrate efficacy in treating leukemia and lymphoma.
- Synthetic biology expands the toolkit for programming immune cells.
- Engineered T cells offer hope for curative cancer responses.
Conclusions:
- Genetically engineered T cells are a powerful new therapeutic modality.
- Advances in T cell engineering and manufacturing will broaden applications.
- T cell therapies hold promise beyond oncology, including infectious diseases, transplantation, and autoimmunity.
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