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In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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The Beneficial Therapy with Colchicine for Atherosclerosis via Anti-inflammation and Decrease in

Michael Spartalis1,2, Eleftherios Spartalis3, Eleni Tzatzaki1

  • 1Division of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.

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Summary

Colchicine, an anti-inflammatory drug, shows promise in managing atherosclerotic disease by reducing inflammation and stabilizing plaques. It may also lower triglyceride levels, though more research is needed on this effect.

Keywords:
Atherosclerosiscolchicinecoronaryinflammationmyocardial infarctiontriglyceride.

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Inflammation Research

Background:

  • Atherosclerotic disease management relies on lipid-lowering and risk factor control.
  • Despite optimal treatment, acute coronary syndrome (ACS) event rates remain high.
  • Inflammation is a critical driver of atherosclerotic plaque development, progression, and rupture, leading to ACS.

Purpose of the Study:

  • To review the therapeutic potential of colchicine for inflammation-mediated atherosclerotic disease.
  • To explore colchicine's effects on hypertriglyceridemia.

Main Methods:

  • A comprehensive literature search was conducted using PubMed.
  • Studies focused on colchicine, atherosclerosis, and hypertriglyceridemia were included.

Main Results:

  • Colchicine exhibits direct anti-inflammatory effects by inhibiting key pathways like the inflammasome.
  • It reduces inflammatory cell recruitment and systemic inflammation, including Interleukin-1 beta (IL-1β) release.
  • Colchicine stabilizes coronary plaques, improves cardiac healing, and reduces ACS recurrence.

Conclusions:

  • Colchicine lowers inflammatory markers, stabilizes plaques, and decreases ACS recurrence.
  • It reduces myocardial infarct size, fibrosis, and improves hemodynamic function.
  • Colchicine may lower triglyceride levels, but the mechanism requires further investigation.