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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
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Senotherapeutics: emerging strategy for healthy aging and age-related disease

Eok-Cheon Kim1, Jae-Ryong Kim1

  • 1Department of Biochemistry and Molecular Biology, Smart-aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu 42415, Korea.

BMB Reports
|December 12, 2018
PubMed

Insights

Cellular senescence, characterized by aging cells, drives age-related diseases. Targeting these senescent cells with senotherapeutics offers a promising strategy to extend health span and combat aging pathologies.

Area of Science:

  • Gerontology
  • Cell Biology
  • Pharmacology

Background:

  • Cellular senescence (CS) is a hallmark of aging, with accumulating senescent cells (SCs) contributing to organismal aging and age-related diseases (ARDs).
  • Genetic elimination of SCs in mice has shown to extend health span and reduce ARDs, indicating a direct link between SCs, longevity, and disease.
  • Senotherapeutics, targeting SCs, represent a potential strategy for health span extension and ARD prevention/treatment.

Purpose of the Study:

  • To review the current development of senotherapeutics.
  • To discuss the role of senotherapeutics in aging and ARDs.
  • To explore future directions and opportunities for senotherapeutics.

Main Methods:

  • Review of existing literature on senotherapeutics, cellular senescence, and age-related diseases.
  • Classification of senotherapeutics into senolytics, senomorphics, and immune-system mediators.
  • Analysis of preclinical data from animal models regarding senotherapeutic efficacy.

Main Results:

  • Senolytics selectively eliminate SCs, while senomorphics modulate SC function or delay senescence.
  • Senotherapeutics have demonstrated significant potential in preventing and treating ARDs in animal models.
  • The development of senotherapeutics is advancing, offering new avenues for health span extension.

Conclusions:

  • Senotherapeutics are a promising approach to address aging and ARDs.
  • Further research and development are needed to translate senotherapeutic benefits to human health.
  • Targeting cellular senescence holds potential for novel interventions against age-related decline and diseases.

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