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Iron Deficiency Anemia Associated With Acid-Modifying Medications: Two Cases and Literature Review.
Ramya Deepthi Vinnakota1, Allan S Brett1
1Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina.
The American Journal of the Medical Sciences
|December 12, 2018
Summary
Gastric acid-suppressive medications like PPIs and H2 blockers, plus calcium carbonate, may cause iron deficiency anemia. Clinicians should monitor patients for this risk, even if uncommon.
Area of Science:
- Gastroenterology
- Hematology
- Clinical Pharmacology
Background:
- Gastric acidity aids nonheme iron absorption; acid-suppressive drugs may impair this.
- Calcium carbonate, an antacid, can also inhibit iron absorption.
- Limited direct clinical evidence links these medications to iron deficiency anemia.
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