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Whey proteins as stabilizers in amorphous solid dispersions.

Jaya Mishra1, Adam Bohr1, Thomas Rades2

  • 1Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|December 12, 2018
PubMed
Summary

Whey proteins, like whey protein isolate and hydrolysate, effectively enhance drug solubility and dissolution rates when used in amorphous solid dispersions. These whey protein formulations significantly improve drug stability compared to pure amorphous drugs.

Keywords:
AmorphousDissolutionPoorly water-soluble drugsSolid dispersionsWhey proteins

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Biochemistry

Background:

  • Whey proteins are common nutritional supplements.
  • Their potential as co-formers for amorphous solid dispersions (ASDs) to improve drug solubility has not been explored.
  • Poorly water-soluble drugs present formulation challenges.

Purpose of the Study:

  • To investigate whey protein isolate (WPI) and whey protein hydrolysate (WPH) as co-formers for ASDs.
  • To enhance the solubility and dissolution rate of poorly water-soluble drugs.
  • To assess the physical stability of whey protein-based ASDs.

Main Methods:

  • ASDs were prepared by mixing WPI or WPH with indomethacin, carvedilol, or furosemide (50% w/w drug loading) using vibrational ball milling.
  • Solid-state characteristics, dissolution rates, and physical stability were analyzed.
  • Drug concentrations and saturation solubilities were measured.

Main Results:

  • All ASDs exhibited increased glass transition temperatures, faster dissolution rates, and higher apparent solubilities compared to pure drugs.
  • Whey proteins increased drug saturation solubility and led to supersaturation.
  • IND-containing ASDs were stable for over 27 months; CAR and FUR ASDs were stable for 8 and 17 months, respectively, outperforming pure amorphous drugs.

Conclusions:

  • WPI and WPH are effective co-formers for creating amorphous solid dispersions.
  • Whey proteins significantly enhance the solubility, dissolution, and physical stability of poorly water-soluble drugs in ASDs.
  • These findings highlight whey proteins as promising amorphous stabilizers for drug formulations.