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Singe nucleotide polymorphisms in osteosarcoma: Pathogenic effect and prognostic significance.

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Single nucleotide polymorphisms (SNPs) impact osteosarcoma (OS) development and patient outcomes. Targeting these genetic variations offers potential therapeutic strategies for this bone cancer.

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Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Osteosarcoma (OS) is a prevalent bone cancer in children and adolescents.
  • Its development and patient prognosis are influenced by genetic and environmental factors.
  • Single nucleotide polymorphisms (SNPs) represent key genetic alterations affecting OS.

Purpose of the Study:

  • To review the role of SNPs in the pathogenesis and prognosis of OS.
  • To explore the potential of SNPs as therapeutic targets for improving patient outcomes.

Main Methods:

  • Literature review of English-language articles (1998-2018).
  • Keywords used: "Single nucleotide polymorphisms", "Osteosarcoma", "Pathogenesis", "Prognosis", "Clinical Outcomes".

Main Results:

  • SNPs influence critical cellular processes in OS, including proliferation, apoptosis, adhesion, invasion, and drug resistance.
  • These genetic variations play a significant role in OS pathogenesis, prognosis, and chemotherapy response.

Conclusions:

  • SNPs can serve as valuable biomarkers for OS pathogenesis and prognosis.
  • Targeting SNPs may lead to novel therapeutic approaches for osteosarcoma.
  • Further research and clinical trials are necessary to fully realize the therapeutic potential of targeting SNPs in OS.