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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Published on: August 18, 2010

Engineering lymphocytes with RNAi.

Srinivas Ramishetti¹, Dan Peer¹

¹Laboratory of Precision NanoMedicine, School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel.

Advanced Drug Delivery Reviews

|December 12, 2018

Summary

This summary is machine-generated.

Restoring lymphocyte function is crucial for treating immune disorders, cancer, and viral infections. Nanotechnology offers promising solutions for delivering RNA interference (RNAi) gene-silencing tools to these hard-to-target immune cells.

Keywords:

Gene silencing Lymphocytes Non-viral vectors Targeting Viral vectors siRNA

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Area of Science:

Immunology
Nanotechnology
Molecular Medicine

Background:

Lymphocytes are key immune cells, but their dysfunction contributes to various diseases.
Current therapies like therapeutic antibodies and CAR-T cells show promise but have limitations.
Effective gene manipulation in lymphocytes is hindered by delivery challenges.

Purpose of the Study:

To review current RNA interference (RNAi) delivery technologies for lymphocytes.
To highlight the importance of targeting strategies for in vivo lymphocyte delivery.
To discuss the potential of RNAi delivery for treating leukocyte-related diseases.

Main Methods:

Review of nanotechnology-based delivery systems for RNAi.
Discussion of targeting molecules for specific lymphocyte subsets.
Analysis of recent advancements in RNAi delivery to lymphocytes.

Main Results:

Nanotechnology provides viable strategies for overcoming lymphocyte transfection barriers.
Targeting molecules are essential for efficient in vivo delivery to dispersed lymphocytes.
Recent developments show progress in delivering RNAi to specific lymphocyte subsets.

Conclusions:

Advanced RNAi delivery systems are critical for restoring lymphocyte function.
Targeted nanotechnology holds significant potential for molecular medicine in leukocyte disorders.
Further research in RNAi delivery will advance treatments for immunological and viral diseases.