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Related Experiment Videos

Ankylosing spondylitis and pregnancy.

G Husby1, M Ostensen, J T Gran

  • 1Department of Rheumatology, University Hospital of Tromso, Norway.

Clinical and Experimental Rheumatology
|April 1, 1988
PubMed
Summary

Pregnancy does not typically induce remission in ankylosing spondylitis (AS) like it does in rheumatoid arthritis (RA). However, women with AS generally experience normal fertility, pregnancy, and birth outcomes, though their children have a slightly increased risk of developing AS.

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Area of Science:

  • Immunology
  • Rheumatology
  • Obstetrics

Background:

  • Rheumatoid arthritis (RA) often shows pregnancy-induced remission.
  • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine.
  • The impact of pregnancy on AS disease activity is less understood compared to RA.

Purpose of the Study:

  • To investigate the effect of pregnancy on ankylosing spondylitis (AS) disease activity.
  • To compare pregnancy outcomes in women with AS to the general population.
  • To assess the risk of AS in offspring of affected mothers.

Main Methods:

  • Observational study comparing pregnant women with AS to controls.
  • Review of fertility rates, pregnancy course, and birth outcomes.

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  • Analysis of familial AS incidence.

    • Main Results:

    • Pregnancy-induced remission, common in RA, was not observed in AS.
    • Women with AS demonstrated comparable fertility, pregnancy progression, and birth rates to the general population.
    • Offspring of mothers with AS showed a slightly elevated risk of developing AS later in life.

    Conclusions:

    • Ankylosing spondylitis (AS) pathogenesis differs from rheumatoid arthritis (RA), explaining the lack of pregnancy-induced remission.
    • Pregnancy in women with AS is generally safe, with normal outcomes for mother and child.
    • Genetic predisposition to AS may be transmitted to offspring, warranting further investigation.