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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Drug Administration and Therapy Phases: Overview01:26

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group Therapy01:26

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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A multifunctional drug nanocarrier for efficient anticancer therapy.

Carmen Teijeiro-Valiño1, Ramon Novoa-Carballal2, Erea Borrajo3

  • 1Department of Pharmacy and Pharmaceutical Technology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 12, 2018
PubMed
Summary

This study introduces novel hyaluronic acid nanocapsules with dual targeting capabilities for enhanced anticancer drug delivery. These nanomedicines show improved tumor penetration, accumulation, and efficacy, significantly reducing tumor growth and metastasis.

Keywords:
Anti-cancer drug deliveryLymphatic targetingMetastasisNanocapsulesTumor homing peptideTumor targeting

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Area of Science:

  • Nanomedicine
  • Oncology
  • Drug Delivery

Background:

  • Anticancer nanomedicines often have limited success due to poor tumor targeting and penetration.
  • Developing nanocarriers with improved targeting and tumor penetration is crucial for effective cancer therapy.

Purpose of the Study:

  • To develop and evaluate a multifunctional drug nanocarrier for enhanced anticancer efficacy.
  • To investigate the dual targeting and tumor penetration capabilities of hyaluronic acid nanocapsules conjugated with tLyp1 peptide.

Main Methods:

  • Fabrication of hyaluronic acid nanocapsules conjugated with the tLyp1 peptide.
  • In vitro evaluation using a 3D co-culture model to assess interaction with NRP1 receptors.
  • In vivo studies in orthotopic lung cancer models and patient-derived pancreatic tumors to assess biodistribution, tumor accumulation, and therapeutic efficacy.

Main Results:

  • Nanocapsules demonstrated interaction with over-expressed NRP1 receptors on cancer cells.
  • Achieved a 37-fold higher docetaxel accumulation in tumors compared to Taxotere®.
  • Showed significant tumor growth regression, reduced lymphatic metastasis, and comparable efficacy to Abraxane® at a lower dose in pancreatic cancer models.

Conclusions:

  • The multifunctional nanocarrier exhibits dual targeting (tumor and lymphatics) and enhanced tumor penetration.
  • This novel nanomedicine platform significantly improves drug biodistribution and therapeutic outcomes in preclinical cancer models.
  • Multi-functionality is identified as a key factor for the success of this advanced cancer therapy.