Related Experiment Video

Updated: Feb 1, 2026

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse
10:31

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse

Published on: August 15, 2019

8.1K

Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The

James D Fortenberry1, Trung Nguyen2, Jocelyn R Grunwell1

  • 1Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta at Egleston, Atlanta, GA.

Critical Care Medicine
|December 12, 2018
PubMed

Insights

Therapeutic plasma exchange (TPE) may improve organ dysfunction and reduce 28-day mortality in children with sepsis-induced thrombocytopenia-associated multiple organ failure. Further research is needed to confirm these findings.

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Intensive care medicine

Background:

  • Sepsis-induced thrombocytopenia-associated multiple organ failure (TA-MOF) presents a significant challenge in pediatric intensive care units (PICUs).
  • Limited evidence exists regarding the efficacy of therapeutic plasma exchange (TPE) in improving outcomes for children with TA-MOF.

Purpose of the Study:

  • To compare the resolution of organ dysfunction, 28-day mortality, and biochemical markers in children with TA-MOF who received TPE versus those who did not.
  • To evaluate the impact of TPE on pediatric organ dysfunction scores and mortality rates.

Main Methods:

  • An observational longitudinal cohort study was conducted across nine U.S. PICUs.
  • Eighty-one children diagnosed with sepsis-induced TA-MOF were included in the analysis.
  • Multivariate regression with propensity score weighting was used to model 28-day mortality and adjust for confounding factors.

Main Results:

  • Children treated with TPE showed a significant decline in Pediatric Logistic Organ Dysfunction (PLOD) scores by day 4 compared to the control group.
  • TPE use was associated with a reduced 28-day all-cause mortality (adjusted relative risk, 0.45; 95% CI, 0.23-0.90).
  • Propensity score weighting analysis also indicated a significant reduction in 28-day mortality with TPE (adjusted relative risk, 0.46; 95% CI, 0.22-0.97).

Conclusions:

  • Therapeutic plasma exchange (TPE) use in children with thrombocytopenia-associated multiple organ failure (TA-MOF) is associated with improved organ dysfunction resolution.
  • TPE treatment was linked to lower 28-day all-cause mortality in this pediatric cohort.
  • A multicenter randomized clinical trial is recommended to establish a definitive causal relationship between TPE and improved outcomes in TA-MOF.
Abstract

More Related Videos

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

11.1K
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

1.6K

Related Concept Videos

Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
30.7K
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
38.1K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.6K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
882
Levels of Organization01:09

Levels of Organization

Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
140.7K
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
1.0K