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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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[ONSTEP procedure for inguinal hernia repair].

A V Smirnov1, D Yu Petrov2, A V Panin3

  • 1Vishnevsky Institute of Surgery of Healthcare Ministry of Russia, Moscow, Russia.

Khirurgiia
|December 12, 2018
PubMed
Summary

The ONSTEP procedure for inguinal hernia repair shows high effectiveness and safety, comparable to the Liechtenstein technique. This study evaluated outcomes, finding similar complication rates and recurrence between the two surgical methods.

Keywords:
Liechtenstein procedureONSTEP hernia repairinguinal herniapreperitoneal hernia repair

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Area of Science:

  • Surgical Innovation
  • Hernia Repair Techniques
  • Minimally Invasive Surgery

Background:

  • Inguinal hernias are common surgical conditions.
  • Traditional hernia repair methods have established outcomes.
  • Evaluating novel techniques is crucial for improving patient care.

Purpose of the Study:

  • To assess the early and long-term results of the ONSTEP procedure for inguinal hernia repair.
  • To compare the ONSTEP technique with the established Liechtenstein hernia repair method.

Main Methods:

  • A two-part study including retrospective and prospective analyses.
  • Retrospective analysis involved 472 patients.
  • Prospective analysis compared 30 patients undergoing ONSTEP repair with 30 patients undergoing Liechtenstein repair.

Main Results:

  • ONSTEP surgery resulted in 2.9% postoperative complications and 0.4% chronic pain syndrome.
  • Two cases of recurrence were observed after the ONSTEP procedure.
  • No significant differences in outcomes were found between the ONSTEP and Liechtenstein procedures.

Conclusions:

  • The ONSTEP technique is a highly effective and safe option for inguinal hernia management.
  • ONSTEP offers comparable outcomes to the Liechtenstein procedure.
  • Further research may explore long-term efficacy and patient-reported outcomes.