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Updated: Feb 1, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
A myocardial infarction may disclose patent foramen ovale
Daniela Trabattoni1, Tiziana Zaro2, Stefano Garducci2
1Centro Cardiologico Monzino, IRCCS, Department of Cardiovascular Sciences, Milan, Italy.
Insights
A young man experienced acute myocardial infarction due to a patent foramen ovale (PFO). PFO closure prevented further paradoxical embolization, highlighting PFO as a potential cause of heart attack in young adults.
Area of Science:
- Cardiology
- Vascular Medicine
- Interventional Cardiology
Background:
- Acute myocardial infarction (MI) in young adults is uncommon.
- Atherosclerotic coronary artery disease is the typical cause of MI.
- Paradoxical embolism through a patent foramen ovale (PFO) is a rare cause of MI.
Purpose of the Study:
- To report a case of acute myocardial infarction in a young adult.
- To investigate the potential embolic source of myocardial infarction.
- To evaluate the efficacy of PFO closure in preventing recurrent paradoxical embolization.
Main Methods:
- Case report of a 19-year-old male with acute myocardial infarction.
- Contrast echocardiography with Valsalva maneuver to detect intracardiac shunting.
- Transcatheter PFO closure using a 23-mm occluder.
- Follow-up contrast transthoracic echocardiography.
Main Results:
- The patient presented with acute myocardial infarction without coronary artery disease.
- A patent foramen ovale with right-to-left shunting was identified as the likely embolic source.
- Successful PFO closure was achieved.
- No residual shunt or recurrent paradoxical embolization was observed at 1-year follow-up.
Conclusions:
- Patent foramen ovale can be a cause of acute myocardial infarction in young individuals.
- PFO closure is an effective treatment to prevent recurrent paradoxical embolization.
- Echocardiography is crucial in identifying PFO as an embolic source.
Abstract:
We report a case of a 19-year-old man presenting with an acute myocardial infarction. Coronary arteries were free from atherosclerotic disease. A patent foramen ovale (PFO) was detected on contrast echocardiography with right-to-left shunting during Valsalva maneuver. No other embolic source was identified. We closed the patient's PFO with a 23-mm PFO occluder. No residual intracardiac shunt was found on contrast transthoracic echocardiography at 1-year follow-up and no recurrent paradoxical embolization occurred.

