Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rapidly Varying Flow01:24

Rapidly Varying Flow

561
Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...
561

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Independent prognostic value of left ventricular stroke volume index in patients with takotsubo syndrome: insights from the EVOLUTION registry.

Heart (British Cardiac Society)·2026
Same author

FFR-CT: Technical Advances and Implementation in Clinical Practice.

Journal of imaging·2026
Same author

Cardiac magnetic resonance-derived left atrioventricular coupling index predicts outcome in reduced ejection fraction.

ESC heart failure·2026
Same author

CMR Findings Across Disease Phases in Takotsubo Syndrome: Insights From the Multicenter EVOLUTION Registry.

The American journal of cardiology·2026
Same author

Cardiac magnetic resonance in acute myocardial infarction undergoing thrombus aspiration.

International journal of cardiology·2026
Same author

CarDiac magnEtic resonance for prophylactic implantable cardioVerter defibrillAtor ThErapy in ischemic dilated CardioMyopathy: Prognostic implication of papillary muscles involvement.

Progress in cardiovascular diseases·2026

Related Experiment Video

Updated: Feb 28, 2026

Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation
06:59

Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation

Published on: June 3, 2018

11.1K

Deep Learning and Fluid Dynamics On-Site CT-FFR Solution Compared to Off-Site FFRct and Invasive FFR.

Fabio Fazzari1, Natallia Khenkina2, Giulia Piccinni3

  • 1Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.

JACC. Cardiovascular Imaging
|February 27, 2026
PubMed
Summary

On-site computed tomography (CT)-derived fractional flow reserve (FFR) analysis using xFFR demonstrates high accuracy for coronary artery disease (CAD) assessment. This rapid, on-site solution offers a promising alternative to off-site methods, improving clinical workflow efficiency.

Keywords:
CT-FFRFFRctcoronary artery diseasecoronary computed tomographyfractional flow reserve

More Related Videos

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
10:44

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

1.3K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.6K

Related Experiment Videos

Last Updated: Feb 28, 2026

Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation
06:59

Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation

Published on: June 3, 2018

11.1K
Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
10:44

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

Published on: June 21, 2024

1.3K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.6K

Area of Science:

  • Cardiovascular Imaging
  • Medical Diagnostics
  • Computational Fluid Dynamics

Background:

  • Growing need for on-site computed tomography (CT)-derived fractional flow reserve (FFR) solutions to overcome limitations of external platforms.
  • Current reliance on off-site analysis for CT-FFR increases delays and costs in diagnosing coronary artery disease (CAD).

Purpose of the Study:

  • To evaluate the diagnostic performance of an on-site deep learning and fluid dynamic-based CT-FFR algorithm (xFFR).
  • To compare the accuracy of on-site xFFR against off-site HeartFlow CT-FFR (FFRct) and invasive FFR (iFFR).

Main Methods:

  • Prospective, single-center study of 250 symptomatic patients with intermediate-to-high CAD risk.
  • Coronary computed tomography angiography (CTA), on-site xFFR, off-site FFRct, and invasive FFR (iFFR) were performed.
  • Diagnostic performance assessed using Areas Under the Curve (AUCs), Spearman's correlations, and Cohen's κ.

Main Results:

  • xFFR detected functionally significant CAD in 56.6% of cases with 95% sensitivity, 81% specificity, and 88% accuracy.
  • Overall diagnostic accuracy of xFFR was comparable to FFRct (AUC: 0.91 vs 0.89), with superior accuracy for LAD assessment (AUC: 0.96 vs 0.84).
  • Mean xFFR analysis time was 8 ± 3.4 minutes, showing good agreement with iFFR (ρ = 0.67).

Conclusions:

  • On-site xFFR is a robust and efficient tool for CAD assessment, exhibiting high diagnostic accuracy and reproducibility.
  • The rapid processing time and integration into clinical workflows position xFFR as a viable alternative to off-site FFRct.
  • Further research is recommended to validate generalizability and optimize clinical implementation of on-site xFFR.