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Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis

Lei Zhang1, Wei-Qiang Tan2, Qing-Qing Fang3

  • 1Department of Orthopaedics, Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou 311201, China.

Biomed Research International
|December 12, 2018
PubMed
Abstract

Insights

Tranexamic acid (TA) effectively reduces melasma severity, as indicated by lower Melasma Area and Severity Index (MASI) scores. While generally safe, minor side effects like gastrointestinal upset were reported in this systematic review.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Melasma is a common, persistent skin pigmentation disorder.
  • Effective and safe treatments are sought for melasma management.

Purpose of the Study:

  • To systematically review and evaluate the efficacy and safety of tranexamic acid (TA) for treating adult melasma.

Main Methods:

  • A systematic review and meta-analysis of 21 eligible trials.
  • Data independently extracted and analyzed using standardized mean differences (SMD) with 95% confidence intervals (CIs).
  • Searched 3 databases up to April 26, 2018.

Main Results:

  • Tranexamic acid (TA) significantly reduced Melasma Area and Severity Index (MASI) and Melanin Index (MI).
  • No significant changes were observed in the Erythema Index (EI).
  • Reported side effects were minor, including mild gastrointestinal reactions and skin irritation.

Conclusions:

  • Tranexamic acid (TA) shows promise as a therapeutic option for melasma.
  • The treatment is associated with a favorable safety profile.

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