Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Social Traps01:41

Social Traps

26.9K
Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
26.9K
Inflammatory Response01:28

Inflammatory Response

16.7K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.7K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

7.8K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.8K
The Extracellular Matrix01:42

The Extracellular Matrix

89.0K
Overview
89.0K
The Extracellular Matrix01:29

The Extracellular Matrix

12.2K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.2K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

16.4K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
16.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endoneurial Eosinophil-Mediated Neural Injury in Eosinophilic Granulomatosis With Polyangiitis.

The Journal of rheumatology·2026
Same author

Mechanisms of Eosinophil Degranulation.

Cells·2026
Same author

Cell-free tumour DNA in bronchoalveolar lavage: a proof of concept study.

ERJ open research·2026
Same author

Eosinophil Essentials: Identification and Assessment of Activity.

Journal of leukocyte biology·2026
Same author

Skin vasculitis and cardiac eosinophil extracellular trap formation in eosinophilic granulomatosis with polyangiitis: a case report.

Modern rheumatology case reports·2026
Same author

[EOSINOPHIL-ASSOCIATED DISEASES: A PATHOBIOLOGY-BASED, CROSS-ORGAN PERSPECTIVE].

Arerugi = [Allergy]·2026

Related Experiment Video

Updated: Feb 1, 2026

Neutrophil Extracellular Traps: How to Generate and Visualize Them
14:17

Neutrophil Extracellular Traps: How to Generate and Visualize Them

Published on: February 24, 2010

88.1K

Eosinophil Extracellular Traps and Inflammatory Pathologies-Untangling the Web!

Manali Mukherjee1, Paige Lacy2, Shigeharu Ueki3

  • 1Department of Medicine, McMaster University and St Joseph's Healthcare, Hamilton, ON, Canada.

Frontiers in Immunology
|December 12, 2018
PubMed
Summary

Eosinophils produce DNA-based extracellular traps (EETs) to fight pathogens. Overproduction of these traps, however, contributes to disease and autoimmunity in chronic inflammation.

Keywords:
ETosisairwayscytolysisdegranulationeosinophilsextracellular trapssputum

More Related Videos

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy
09:14

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy

Published on: October 19, 2017

10.9K
In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages
08:08

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

Published on: November 1, 2019

10.5K

Related Experiment Videos

Last Updated: Feb 1, 2026

Neutrophil Extracellular Traps: How to Generate and Visualize Them
14:17

Neutrophil Extracellular Traps: How to Generate and Visualize Them

Published on: February 24, 2010

88.1K
Visualizing Macrophage Extracellular Traps Using Confocal Microscopy
09:14

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy

Published on: October 19, 2017

10.9K
In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages
08:08

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

Published on: November 1, 2019

10.5K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Eosinophils, white blood cells, have complex immune functions.
  • Traditionally linked to parasite defense, they also combat bacterial, viral, and fungal infections.

Purpose of the Study:

  • To discuss the discovery and characterization of eosinophil extracellular traps (EETs).
  • To explore the role of EETs in disease pathogenesis and autoimmunity.

Main Methods:

  • Review of existing literature on eosinophil extracellular traps (EETs).
  • Characterization of EETs in response to various stimuli.

Main Results:

  • Eosinophils produce DNA-based extracellular traps (EETs) that entrap pathogens.
  • EETs act as scaffolds for antimicrobial mediators.
  • Overproduction of EETs is implicated in disease pathologies.

Conclusions:

  • Eosinophil extracellular traps (EETs) play a dual role in immunity and disease.
  • EETs contribute to pathogenesis and autoimmunity in chronic inflammation.